Immunology R&D organization is expanding its early discovery team at the Cambridge Research Center (CRC) in Cambridge, MA. We are seeking a highly motivated contractor/Scientist III to join the Tissue Homeostasis team. Immune‐mediated inflammatory diseases (IMIDs) pose a high burden on the healthcare system worldwide. Long term remission from IMIDs represents an unmet need. Current therapeutic options that target the stromal compartments are limited, thus highlighting the urgent need to identify and validate novel stromal targets. At Tissue Homeostasis, we aim at deciphering the molecular mechanisms that perpetuate chronic inflammation across different tissues, with the ultimate goal to develop transformative therapeutics that can achieve IMID remission. In particular, we focus on understanding the stromal cell biology in the context of chronic inflammation and tissue damage/pathology. Key questions include but not limited to 1) how stromal cells communicate with immune cells to maintain homeostatic states of tissues; 2) how dysregulation of cell-cell and cell-extracellular matrix (ECM) interactions may contribute to inflammatory disorders; and 3) how key signaling aspects of tissue biology in health and IMIDs can be recapitulated in multi-cellular coculture systems or complex in vitro systems. As a contractor/Scientist III , the candidate will participate in target validation and assay development efforts with a focus on dissecting the molecular mechanisms underlying stromal inflammation. This is a hands-on and lab-based role requiring significant cell biology and immunology expertise, the ability to critically assess literature knowledge, and design experiments to support target validation and platform building processes in the Tissue Homeostasis team.
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EEO:
“Mindlance is an Equal Opportunity Employer and does not discriminate in employment on the basis of – Minority/Gender/Disability/Religion/LGBTQI/Age/Veterans.”
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